DNA polymerases orchestrate the faithful replication and repair of genomes through a coordinated sequence of substrate binding, chemical catalysis and product release. Central to this process are ...
DNA polymerases rely on divalent metal ions to catalyse the nucleotidyl transfer reaction and to ensure high fidelity during genome replication and repair. The classical two-metal-ion mechanism ...
Biology lectures teach students that when a cell’s replication machinery comes together, DNA polymerase takes off down the double-helix like a car on a highway ...
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